Type 1 lepra reaction presenting as immune reconstitution inflammatory syndrome

Type 1 lepra reaction presenting as immune reconstitution inflammatory syndrome.

Indian J Dermatol Venereol Leprol | May-June 2008 | Vol 74 | Issue 3 does not have any effect after 72 hrs, the steroids given early and for a short duration may help improve the prognosis. Since cyclosporine is reported to be effective in TEN by interrupting the disease progression and decreasing the time taken for complete re-epithelization, we feel that the combination of initial high dose o...

Reversal Reaction as a Manifestation of Immune Reconstitution Inflammatory Syndrome

Immune reconstitution inflammatory syndrome.

Immune reconstitution inflammatory syndrome (IRIS) is a collection of inflammatory disorders associated with paradoxical worsening of preexisting infectious processes after the initiation of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected individuals. At the initial stage of the disease, the imaging findings can be misdiagnosed as pneumonia resulting ...

Leukocyte Adhesion Deficiency Type 1 Presenting as Leukemoid Reaction

The hallmarks of leukocyte adhesion deficiency (LAD) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. These molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. Over las...

Susac’s syndrome as HIV-associated immune reconstitution inflammatory syndrome

Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (cART). Corticosteroids and intravenous immunoglobulins alone did not control t...